FLIPI

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Use this calculator to calculate prognosis in follicular lymphoma using the Follicular Lymphoma International Prognostic Index (FLIPI).

Age > 60?
Number of Nodal Sites
LDH
Hemoglobin
Stage

About this calculator

The Follicular Lymphoma International Prognostic Index (FLIPI) is the result of a large international cooperative effort in which clinical data was collected from 4167 patients with FL diagnosed between 1985 and 1992. From this database, a prognostic index with five adverse factors was derived and validated. The index is able to separate 3 risk groups of approximately eqaul size with clear differentiation of long-term prognosis.

Prognosis depends on the sum of 5 factors: number of Nodal areas, LDH, Age, Stage, and Hemoglobin level. Hence, the mnemonic NoLASH may be useful to remember the factors.

If the score is 0 to 1, the patient is considered “low risk” according to the FLIPI. Overall survival at 10 years is estimated to be 70%. If the score is 2, the patient is considered “intermediate risk” according to the FLIPI. Overall survival at 10 years is estimated to be 50%. If the score is ≥ 3, the patient is considered “high risk” according to the FLIPI. Overall survival at 10 years is estimated to be 35%.

Citation

The FLIPI was proposed and validated by revised/developed by Solal-Celigny et al. Follicular Lymphoma International Prognostic Index. Blood 104:1258-1265. (2004)

Contributor

QxMD Hematology contributing author: Dr. Matthew Cheung, MD, SM, FRCP(C)