MDS Prognosis | IPSS

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Use this calculator to determine the Myelodysplastic Syndrome International Prognostic Scoring System (IPSS).

Percentage of bone marrow blasts
Karyotype*
Number of cytopenias†

*Karytope defined as Good: Normal, -Y, del(5q), del(20q); Poor: chromosome 7 anomalies, complex (3 or more abnormalities); and Intermediate: all others. †Cytopenias defined as Hb <100g/L, ANC < 1,800/uL, and platelets < 100,000/mm3.

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About this calculator

Myelodysplastic syndromes are a heterogeneous group of diseases with variable outcomes. Patients with low-risk disease often have longer survivals and the primary therapeutic goals include improvement of ineffective hematopoiesis and reduction of iron overload. Higher risk patients are managed with the goal of delaying transformation to acute leukemia and extending survival. The International Prognostic Scoring System is the most commonly used tool in MDS to predict long-term outcome.

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Citation

The IPSS was developed and validated by Greenberg et al. International Scoring System for Evaluating Prognosis in Myelodysplastic Syndromes. Blood 89:2079-2088. (1997)

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Contributor

QxMD Hematology contributing author: Dr. Matthew Cheung, MD, SM, FRCP(C)