Mantle Cell MIPI

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Use this calculator to determine prognosis in Mantle Cell Lymphoma using the Mantle Cell Lymphoma International Prognostic Index (MIPI).

When the cell proliferation index (Ki-67) is not available:

Age
ECOG* score
LDH
LDH upper limit of normal for your lab
WBC count (109 per litre)

When the cell proliferation index (Ki-67) is available

Age
ECOG* Score
LDH
LDH upper limit of normal for your lab
WBC count (109 per litre)
Ki67 – cell proliferation index (%)

*ECOG: Eastern Cooperative Oncology Group scale, in which 0 indicates that the patient has no symptoms, 1 indicates that the patient has symptoms but is ambulatory, 2 indicates that the patient is bedridden less than half the day, 3 indicates that the patient is bedridden half the day or longer, and 4 indicates the patient is chronically bedridden and requires assistance with the activities of daily living.

About this calculator

The Mantle Cell Lymphoma International Prognostic Index (MIPI) was derived from a data set of 455 advanced stage MCL patients treated in series of clinical trials in Germany, Europe. Of the evaluable population, approximately 18% were treated with high-dose therapy and stem cell transplantation in first remission. The MIPI is able to classify patients into three risk groups: low risk (median survival not reached after median 32 months follow-up and 5-year OS rate of 60%), intermediate risk (median survival 51 months) and high risk (median survival 29 months). In addition to the 4 independent prognostic factors included in the model, the cell proliferation index (Ki-67) was also shown to have additional prognostic relevance. When the Ki67 is available, a biologic MIPI (MIPIb) can be calculated. Risk group is assigned based on MIPI score prior to rounding.

Citation

The MIPI was proposed and validated by Hoster et al. A new prognostic index (MIPI) for patients with advanced-stage mantle cell lymphoma. Blood 111:558-565. (2008)

Contributor

QxMD Hematology contributing author: Dr. Matthew Cheung, MD, SM, FRCP(C)