Adequacy and Ultrafiltration Goals

• The minimum delivered weekly Kt/V_urea of 1.7 represents peritoneal clearance alone or peritoneal plus renal clearance¹¹
• While the Kidney Disease Outcomes Quality Initiative (KDOQI) guidelines do not recommend use of creatinine clearance to assess adequacy, creatinine clearance goals are advocated by the International Society of Peritoneal Dialysis (ISPD) and other organizations^1-6
• Euvolemia is critical to improve patient outcomes¹
• While no recommendation regarding an ultrafiltration (UF) target exists in the United States, other countries recommend an arbitrary UF target of 750-1000 mL/day in anuric patients, based upon improved outcomes in observational studies^{4, 5, 7}

Reminder: Adequacy is not just about Kt/V

« Previous