PD Prescription Guide: Volume of Distribution of Urea

Volume of Distribution of Urea (Vurea)

A simple method for determining the volume of urea distribution is to estimate the patient’s total body water (TBW). It is important to note that different equations exist for estimating total body water, and using a different equation may give different values. The anthropometric volume of distribution of urea may be calculated by one of the following formulas based on age, height, weight and gender. These are derived from estimates of total body water in healthy subjects.

Watson and Watson:8
Male TBW =

2.447 – (0.09156 x age [years])
+ (0.1074 x height [cm]) + (0.3362 x weight [kg])

Female TBW =  -2.097 + (0.1069 x height [cm]) + (0.2466 x weight [kg])

Hume-Weyers:9
Male TBW =  (0.194786 x height [cm]) + (0.296785 x weight [kg]) – 14.012934

Female TBW =  (0.34454 x height [cm]) + (0.183809 x weight [kg]) – 35.270121

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