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Efficacy of voriconazole in a guinea pig model of disseminated invasive aspergillosis.

W R Kirkpatrick, R K McAtee, A W Fothergill, M G Rinaldi, T F Patterson
Antimicrobial Agents and Chemotherapy 2000 October
Voriconazole (VRC) was evaluated in an immunosuppressed-guinea pig model of invasive aspergillosis. VRC was more effective than amphotericin B or similar doses of itraconazole in the clearance of Aspergillus from tissues. VRC treatment regimens improved survival and significantly reduced tissue colony counts compared with those of controls.

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