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CLINICAL TRIAL
CLINICAL TRIAL, PHASE I
LETTER
RESEARCH SUPPORT, U.S. GOV'T, P.H.S.
Treatment of solid tumours in children with tumour-lysate-pulsed dendritic cells.
Lancet 2000 September 31
Dendritic cells are potent stimulators of antigen-specific immune responses, including antitumour responses. We explored the use of tumour-lysate-pulsed dendritic cells in children with relapsed solid tumours. Dendritic cell treatment in children was feasible and apparently not toxic. The treatment was able to produce significant tumour regression in a child with metastatic fibrosarcoma.
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