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Spontaneous intracranial bleeding in two patients with congenital afibrinogenaemia and the role of replacement therapy.

R Parameswaran, J P Dickinson, S de Lord, D M Keeling, B T Colvin
Haemophilia : the Official Journal of the World Federation of Hemophilia 2000 November
Congenital afibrinogenaemia and hypofibrinogenaemia are rare disorders of haemostasis. In this case report the problems posed in the management of two patients with fibrinogen levels less than 0.1g L(-1) and who developed intracranial bleeding are considered. The value of fibrinogen concentrate and the role of prophylaxis is also discussed.

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