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JOURNAL ARTICLE
RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
The effect of dietary intervention on lipid profiles in individuals with spinal cord injury.
OBJECTIVE: The purpose of this study was to evaluate the effects of a simple dietary intervention for individuals with chronic spinal cord injury (SCI) and moderately elevated total cholesterol.
METHODS: Baseline and follow-up serum lipid values were obtained on 222 persons with SCI. Eighty-six individuals with total cholesterol >200 mg/dL were referred for dietary consultation (group 1). The remainder with values <200 mg/dL and no consultation served as controls (group 2).
RESULTS: At average follow-up of 16 months, group 1 demonstrated significant declines in total cholesterol and low-density lipoprotein cholesterol (LDL-C), whereas group 2 demonstrated significant increases in total cholesterol. Triglyceride levels followed similar but nonsignificant patterns. There were no significant changes in high-density lipoprotein cholesterol for either group. In group 1, 17% had clinically significant reductions in total cholesterol to <200 mg/dL and 21% had reductions of LDL-C from >135 mg/dL to <135 mg/dL.
CONCLUSIONS: Dietary intervention should be an initial treatment for those with SCI and moderately elevated total cholesterol, with the expectation that approximately 20% will respond favorably.
METHODS: Baseline and follow-up serum lipid values were obtained on 222 persons with SCI. Eighty-six individuals with total cholesterol >200 mg/dL were referred for dietary consultation (group 1). The remainder with values <200 mg/dL and no consultation served as controls (group 2).
RESULTS: At average follow-up of 16 months, group 1 demonstrated significant declines in total cholesterol and low-density lipoprotein cholesterol (LDL-C), whereas group 2 demonstrated significant increases in total cholesterol. Triglyceride levels followed similar but nonsignificant patterns. There were no significant changes in high-density lipoprotein cholesterol for either group. In group 1, 17% had clinically significant reductions in total cholesterol to <200 mg/dL and 21% had reductions of LDL-C from >135 mg/dL to <135 mg/dL.
CONCLUSIONS: Dietary intervention should be an initial treatment for those with SCI and moderately elevated total cholesterol, with the expectation that approximately 20% will respond favorably.
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