We have located links that may give you full text access.
JOURNAL ARTICLE
RESEARCH SUPPORT, NON-U.S. GOV'T
REVIEW
Perfluorocarbon for organ preservation before transplantation.
Transplantation 2002 December 28
Perfluorocarbons (PFC) are hydrocarbons in which all or most of the hydrogen atoms have been replaced with fluorine. PFC have a very high capacity for dissolving oxygen (O2 ), and a negligible oxygen-binding constant allows them to release O2 more effectively than hemoglobin into the surrounding tissue. As a result of this unique property, PFC-based solutions have been examined as oxygen carriers. PFC was first used for organ preservation as a component of the two-layer method (TLM) (University of Wisconsin [UW] solution-perfluorochemical plus oxygen) of pancreas preservation. Pancreata preserved in the TLM are oxygenated through the PFC and substrates are supplied by the UW solution. This allows pancreata stored in the TLM to generate adenosine triphosphate during storage and prolong the preservation period. In the canine model, TLM has been shown to repair and resuscitate warm ischemically injured pancreata during preservation, improve pancreas graft survival after transplantation, and improve islet yields after isolation. Current clinical trials using the TLM of pancreas preservation before whole-pancreas transplantation and islet isolation show promising results. The TLM has also been shown to be beneficial for preserving other difficult organs, such as heart and small bowel.
Full text links
Related Resources
Trending Papers
Heart failure with preserved ejection fraction: diagnosis, risk assessment, and treatment.Clinical Research in Cardiology : Official Journal of the German Cardiac Society 2024 April 12
Proximal versus distal diuretics in congestive heart failure.Nephrology, Dialysis, Transplantation 2024 Februrary 30
Efficacy and safety of pharmacotherapy in chronic insomnia: A review of clinical guidelines and case reports.Mental Health Clinician 2023 October
World Health Organization and International Consensus Classification of eosinophilic disorders: 2024 update on diagnosis, risk stratification, and management.American Journal of Hematology 2024 March 30
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app