Urologic manifestations of nonurologic disease urolithiasis.

Patients with nephrolithiasis may have coexistent diseases that play a causative role in stone formation. A stone event may be the initial manifestation of the disorder and the urologist may play a major diagnostic role. Regulation or correction of the disorder may eradicate or dramatically attenuate stone activity. In some patients, metabolic abnormalities persist, however, and the therapeutic strategies that were reviewed in this manuscript may need to be implemented. Stone disease may also be induced by drugs that are used to treat a number of disease processes. When this occurs, the drug will usually need to be discontinued and alternative therapy should be instituted.