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JOURNAL ARTICLE
RESEARCH SUPPORT, NON-U.S. GOV'T
Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism.
Nature Genetics 2003 May
Many studies have supported a genetic etiology for autism. Here we report mutations in two X-linked genes encoding neuroligins NLGN3 and NLGN4 in siblings with autism-spectrum disorders. These mutations affect cell-adhesion molecules localized at the synapse and suggest that a defect of synaptogenesis may predispose to autism.
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