We have located links that may give you full text access.
CLINICAL TRIAL
JOURNAL ARTICLE
RANDOMIZED CONTROLLED TRIAL
RESEARCH SUPPORT, NON-U.S. GOV'T
The role of hypoxia in the limbal vascular response to soft contact lens wear.
Eye & Contact Lens 2003 January
PURPOSE: Increases in limbal vascular blood flow frequently occur as an accompaniment to conventional soft contact lens wear. This study attempted to discover whether these changes can be induced by the direct influence of oxygen alone in the absence of contact lenses.
METHODS: Nine people were subjected to monocular anoxia by bathing one randomly chosen eye with 100% nitrogen using gas-tight goggles. Their other eyes served as controls and were exposed to normal air throughout the study. Vascular changes were quantified by image capture and subsequent analysis, with the change in the proportion of the image corresponding to blood vessels (per area) being used as the measure of hyperemia.
RESULTS: Nitrogen-exposed eyes showed significantly greater hyperemia (mean perarea change +/- 95% confidence interval, 0.023 +/- 0.016 compared with control eyes, -0.013 +/- 0.013; P=0.004, paired t test).
CONCLUSION: Reduced oxygen concentration at the ocular surface induces more blood flow in limbal vessels. This result provides further evidence that similar changes occurring during soft contact lens wear are caused by lens-induced hypoxia.
METHODS: Nine people were subjected to monocular anoxia by bathing one randomly chosen eye with 100% nitrogen using gas-tight goggles. Their other eyes served as controls and were exposed to normal air throughout the study. Vascular changes were quantified by image capture and subsequent analysis, with the change in the proportion of the image corresponding to blood vessels (per area) being used as the measure of hyperemia.
RESULTS: Nitrogen-exposed eyes showed significantly greater hyperemia (mean perarea change +/- 95% confidence interval, 0.023 +/- 0.016 compared with control eyes, -0.013 +/- 0.013; P=0.004, paired t test).
CONCLUSION: Reduced oxygen concentration at the ocular surface induces more blood flow in limbal vessels. This result provides further evidence that similar changes occurring during soft contact lens wear are caused by lens-induced hypoxia.
Full text links
Related Resources
Trending Papers
Proximal versus distal diuretics in congestive heart failure.Nephrology, Dialysis, Transplantation 2024 Februrary 30
World Health Organization and International Consensus Classification of eosinophilic disorders: 2024 update on diagnosis, risk stratification, and management.American Journal of Hematology 2024 March 30
Heart failure with preserved ejection fraction: diagnosis, risk assessment, and treatment.Clinical Research in Cardiology : Official Journal of the German Cardiac Society 2024 April 12
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app