Are proton pump inhibitors indicated for the treatment of gastroesophageal reflux in infants and children?

SUMMARY: Randomized controlled trials in the pediatric population that support the efficacy of proton pump inhibitors for the treatment of gastroesophageal reflux (GER) are lacking. Studies are needed to establish the safety of long-term acid suppression in infants and children, as well as to confirm a causal relationship between GER and extraesophageal symptoms and signs.