Fixed drug eruption - a sexually inducible reaction?

We present three cases of diagnosed fixed drug eruption (FDE) in male patients with known drug sensitivity. In each case, the patient has refrained strictly from intake of the offending agent over many years. FDE developed after history of sexual contact with their spouses who were found to be receiving the same medication to which their partners were hypersensitive. We hypothesized that sexual transfer of the drug antigen occurs through the vaginal fluid on the sensitized area of the male genitalia.