Invasive fungal rhinosinusitis in immunocompromised patients.

INTRODUCTION: Invasive fungal rhinosinusitis (IFR) is one of the most important causes of morbidity and mortality in immunocompromised patients, principally those with cellular immunodeficiency, with mortality ranging from 50 to 80%. Prophylaxis and early diagnosis increase the chances of successful treatment.

STUDY DESIGN: Clinical prospective randomized study.

AIM: To present cases of IFR and to compare them with data reported in the literature.

MATERIAL AND METHODS: Analysis of eleven cases of IFR confirmed by pathologist examination.

RESULTS: Aspergillus was found to be the most prevalent pathogen. Symptoms ranged from high fever in most cases to nasal discharge, ulceration of the nasal mucosa, headache and periorbital edema.

CONCLUSION: The combination of amphotericin B and endoscopic surgery, associated or not with Caldwell-Luc surgery, showed good results. The use of liposomal amphotericin B also presented a satisfactory outcome.