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Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
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The immunoepidemiology of human hookworm infection.

R J Quinnell, J Bethony, D I Pritchard
Parasite Immunology 2004 November
Advances in hookworm immunoepidemiology are reviewed. Recent studies demonstrate a mixed Th1/Th2 response in human hookworm infection, with immunosuppression of specific and nonspecific IFN-gamma responses. There is increasing evidence for protective immunity in human hookworm infection, including anti-larval IL-5- and IgE-dependent mechanisms, and for immunological interactions between hookworm infection and other diseases.

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