Inflammatory, atherothrombotic aspects of type 2 diabetes.

BACKGROUND: There is a tight association between diabetes and cardiovascular disease - both occur more commonly together than independently. The development of vascular disease is dependent upon complex interactions between a number of metabolic pathways involving both fluid phase proteins and cellular components. Inflammation and coagulation are two intimately linked processes that are co-regulated. The characteristic cluster of risk factors - hypertension, hyperinsulinaemia, hyperglycaemia and lipid abnormalities, which are associated with insulin resistance - have been expanded to include inflammation and thrombotic risk. Studies in patients with diabetes indicate a higher prevalence of both inflammatory cells and thrombosis in coronary plaques in comparison to non-diabetic subjects and measures of C-reactive protein predict the development of both diabetes and cardio vascular disease in prospective studies.

SCOPE: This review (based on MEDLINE searches, 1990 to 2005) looks at the inflammatory, atherothrombotic aspects of type 2 diabetes that may be involved in the accelerated development of vascular disease in the population with diabetes.