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Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.
Effect of genetic modifiers on cerebral lesions in Fabry disease.
Neurology 2005 June 29
Fabry disease is associated with increased risk of premature stroke and presumptive ischemic cerebral lesions. In 57 consecutive patients, 35% of whom had lesions on brain MRI, the authors found that genotypes of polymorphisms G-174C of interleukin-6, G894T of endothelial nitric oxide synthase, factor V G1691A mutation, and the A-13G and G79A of protein Z were all significantly associated with cerebral lesions. These findings suggest that these proteins modulate Fabry cerebral vasculopathy.
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