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CASE REPORTS
JOURNAL ARTICLE
Hepatitis after germander (Teucrium chamaedrys) administration: another instance of herbal medicine hepatotoxicity.
Annals of Internal Medicine 1992 July 16
OBJECTIVE: To show that germander (Teucrium chamaedrys), an herbal medicine used to facilitate weight loss, may be hepatotoxic and to delineate the nature of the injury.
DESIGN: Retrospective study.
SETTING: Liver units of several centers in the French Network of Pharmacovigilance.
PATIENTS: Seven patients who developed hepatitis after germander administration and who had no other cause of liver injury.
MEASUREMENTS: Clinical examination, liver function tests, various serologic tests, ultrasonography, and histologic study.
RESULTS: Hepatitis characterized by jaundice and a marked increase in serum aminotransferase levels occurred 3 to 18 weeks after germander administration. Liver biopsy specimens in three patients showed hepatocyte necrosis. After discontinuing treatment with germander, jaundice disappeared within 8 weeks and recovery was complete in 1.5 to 6 months. In three cases, germander readministration was followed by the prompt recurrence of hepatitis.
CONCLUSION: Germander may be hepatotoxic, which supports the view that herbal medicines are not always as safe as generally assumed.
DESIGN: Retrospective study.
SETTING: Liver units of several centers in the French Network of Pharmacovigilance.
PATIENTS: Seven patients who developed hepatitis after germander administration and who had no other cause of liver injury.
MEASUREMENTS: Clinical examination, liver function tests, various serologic tests, ultrasonography, and histologic study.
RESULTS: Hepatitis characterized by jaundice and a marked increase in serum aminotransferase levels occurred 3 to 18 weeks after germander administration. Liver biopsy specimens in three patients showed hepatocyte necrosis. After discontinuing treatment with germander, jaundice disappeared within 8 weeks and recovery was complete in 1.5 to 6 months. In three cases, germander readministration was followed by the prompt recurrence of hepatitis.
CONCLUSION: Germander may be hepatotoxic, which supports the view that herbal medicines are not always as safe as generally assumed.
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