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JOURNAL ARTICLE
REVIEW
Tumor lysis syndrome: pathophysiology, definition, and alternative treatment approaches.
Clinical Advances in Hematology & Oncology : H&O 2005 January
Tumor lysis syndrome (TLS), a life threatening metabolic syndrome seen in malignancies with high tumor burden, is reviewed in this article. The new Cairo and Bishop classification system is discussed as well as the clinical management of this syndrome. Special emphasis is placed on the use of a relatively new agent, rasburicase, as an alternative to allopurinol in the management of TLS-associated hyperuricemia.
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