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Improvement of tardive dyskinesia following amisulpride treatment.

Tardive dyskinesia (TD) is a persistent, disturbing side effect of antipsychotic drug treatment. It is established that clozapine and other second generation agents cause less TD and may also improve pre-existing TD. We report a case of significant improvement of TD after the administration of amisulpride, a potential D(2)/D(3) antagonist that has atypical properties. The possible effect of fast dissociation of D(2) receptors is being discussed.

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