We have located links that may give you full text access.
JOURNAL ARTICLE
RESEARCH SUPPORT, N.I.H., EXTRAMURAL
REVIEW
Postprandial hyperglycemia and cardiovascular disease.
Endocrine Practice 2006 January
OBJECTIVE: To review the role of postprandial hyperglycemia in the development of type 2 diabetes mellitus and cardiovascular disease.
METHODS: The pathogenic mechanisms involved in the deterioration of glucose tolerance are discussed, and findings from relevant epidemiologic and clinical interventional studies are presented.
RESULTS: It is now well established that hyperglycemia is an independent risk factor for cardiovascular disease, with no apparent threshold. In clinical practice, glycemic exposure is measured by hemoglobin A1c levels. These values reflect the contribution of fasting and postprandial plasma glucose levels during the previous 2 to 3 months. Epidemiologic studies have indicated that, at hemoglobin A1c levels (5.5%) already associated with a substantially increased risk for cardiovascular mortality, fasting plasma glucose levels are generally normal. These observations implicate isolated postprandial hyperglycemia as a cardiovascular risk factor. Controlled interventional clinical trials have found that reduction of postprandial hyperglycemia decreases cardiovascular events or surrogates thereof.
CONCLUSION: Postprandial hyperglycemia should be considered a cardiovascular risk factor similar to hypertension, hyperlipidemia, and smoking; accordingly, it should be monitored and treated.
METHODS: The pathogenic mechanisms involved in the deterioration of glucose tolerance are discussed, and findings from relevant epidemiologic and clinical interventional studies are presented.
RESULTS: It is now well established that hyperglycemia is an independent risk factor for cardiovascular disease, with no apparent threshold. In clinical practice, glycemic exposure is measured by hemoglobin A1c levels. These values reflect the contribution of fasting and postprandial plasma glucose levels during the previous 2 to 3 months. Epidemiologic studies have indicated that, at hemoglobin A1c levels (5.5%) already associated with a substantially increased risk for cardiovascular mortality, fasting plasma glucose levels are generally normal. These observations implicate isolated postprandial hyperglycemia as a cardiovascular risk factor. Controlled interventional clinical trials have found that reduction of postprandial hyperglycemia decreases cardiovascular events or surrogates thereof.
CONCLUSION: Postprandial hyperglycemia should be considered a cardiovascular risk factor similar to hypertension, hyperlipidemia, and smoking; accordingly, it should be monitored and treated.
Full text links
Related Resources
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app