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CLINICAL TRIAL
JOURNAL ARTICLE
Infliximab in Takayasu arteritis: a safe alternative?
Clinical Rheumatology 2007 June
OBJECTIVE: To test the efficacy of Infliximab, a chimeric monoclonal antibody against TNF-alpha, in the treatment of Takayasu arteritis.
MATERIALS AND METHODS: We used infliximab at an initial dose of 3 mg/kg i.v. at weeks 0, 2, 6, and 8 thereafter in combination with methotrexate or azathioprine, to treat four patients with Takayasu arteritis.
RESULTS: Three out of four patients responded to infliximab treatment, while two of them retained the response during a two-year follow up. A higher dose regimen (5 mg/kg), however, was eventually warranted for two of the responders. No major side effects were noted.
CONCLUSIONS: Infliximab might be an effective and safe alternative for patients with Takayasu arteritis.
MATERIALS AND METHODS: We used infliximab at an initial dose of 3 mg/kg i.v. at weeks 0, 2, 6, and 8 thereafter in combination with methotrexate or azathioprine, to treat four patients with Takayasu arteritis.
RESULTS: Three out of four patients responded to infliximab treatment, while two of them retained the response during a two-year follow up. A higher dose regimen (5 mg/kg), however, was eventually warranted for two of the responders. No major side effects were noted.
CONCLUSIONS: Infliximab might be an effective and safe alternative for patients with Takayasu arteritis.
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