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Randomized Controlled Trial
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Sodium valproate vs phenytoin in status epilepticus: a pilot study.

U K Misra, Jayantee Kalita, Rajesh Patel
Neurology 2006 July 26
Sixty-eight patients with convulsive status epilepticus (SE) were randomly assigned to two groups to study the efficacy of sodium valproate (VPA) and phenytoin (PHT). Seizures were aborted in 66% in the VPA group and 42% in the PHT group. As a second choice in refractory patients, VPA was effective in 79% and PHT was effective in 25%. The side effects in the two groups did not differ. Sodium valproate may be preferred in convulsive SE because of its higher efficacy.

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