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Journal Article
Meta-Analysis
Review
Proliferative verrucous leukoplakia and its progression to oral carcinoma: a review of the literature.
Journal of Oral Pathology & Medicine 2007 May
BACKGROUND: Proliferative verrucous leukoplakia (PVL) is a distinct clinical form of oral leukoplakia defined by its progressive clinical course, changing clinical and histopathological features, and potential to develop into cancer. PVL behaves in a more aggressive and relentless manner than the more innocuous white oral lesions that it can resemble clinically.
METHODS: A PubMed search was conducted which identified studies that examined patients with PVL and reported data meeting inclusion criteria.
RESULTS: PVL is seen much more frequently in females and most often diagnosed after the sixth decade of life. Tobacco use is not strongly linked to the presence of PVL (63% of patients did not use tobacco products). Most (74%) of the patients with PVL progressed to oral carcinoma.
CONCLUSION: PVL is a persistent and progressive oral lesion that requires very close follow-up along with early and aggressive treatment to increase the chances of a favorable outcome.
METHODS: A PubMed search was conducted which identified studies that examined patients with PVL and reported data meeting inclusion criteria.
RESULTS: PVL is seen much more frequently in females and most often diagnosed after the sixth decade of life. Tobacco use is not strongly linked to the presence of PVL (63% of patients did not use tobacco products). Most (74%) of the patients with PVL progressed to oral carcinoma.
CONCLUSION: PVL is a persistent and progressive oral lesion that requires very close follow-up along with early and aggressive treatment to increase the chances of a favorable outcome.
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