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RESEARCH SUPPORT, N.I.H., EXTRAMURAL
RESEARCH SUPPORT, NON-U.S. GOV'T
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Variation in complement factor 3 is associated with risk of age-related macular degeneration.

Julian B Maller, Jesen A Fagerness, Robyn C Reynolds, Benjamin M Neale, Mark J Daly, Johanna M Seddon
Nature Genetics 2007 October
The association of variants in complement factors H and B with age-related macular degeneration has led to more intense genetic and functional analysis of the complement pathway. We identify a nonsynonymous coding change in complement factor 3 that is strongly associated with risk of age-related macular degeneration in a large case-control sample.

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