We have located links that may give you full text access.
JOURNAL ARTICLE
META-ANALYSIS
REVIEW
Genital ulcerative disease and sexually transmitted urethritis and circumcision: a meta-analysis.
International Journal of STD & AIDS 2007 December
The objective of the study was to determine the relationship of circumcision status to the risk for genital ulcerative disease (GUD) and sexually transmitted urethritis. A MEDLINE search and a review of references in published articles identified studies addressing the risk of sexually transmitted urethritis or GUD based on circumcision status. Meta-analyses, sensitivity analysis, and exploration for publication bias were performed. Thirty articles fulfilled the inclusion criteria. The data from one study were published twice. GUD showed a trend towards being more common in genitally intact men (random-effects summary odds ratio [OR] = 1.34, 95% confidence interval [CI] = 0.98-1.82). When comparing men with GUD to men with 'genital discharge syndrome' (GDS), genitally intact men were more likely to have GUD (OR = 2.31, 95% CI = 1.70-3.15). There was no difference in the risk for chancroid based on circumcision status (OR = 0.91, 95% CI = 0.40-2.05), gonorrhoea (OR = 1.03, 95% CI = 0.82-1.29), or Chlamydia trachomatis infections (OR = 0.62, 95% CI = 0.32-1.19). Genitally intact men were less likely to be diagnosed with 'GDS' (OR = 0.83, 95% CI = 0.67-1.01) or non-specific urethritis (OR = 0.80, 95% CI = 0.64-1.01). Adjustment for publication bias in the literature that applies to chlamydial infections gave a summary OR of 0.46 (95% CI = 0.22-0.97). Significant between-study heterogeneity was a consistent finding. In conclusion, genitally intact men may be at greater risk for GUD, whereas circumcised men may be at greater risk for acquiring sexually transmitted urethritis in general, but there is no statistically significant difference in risk of gonococcal infection. Significant between-study heterogeneity and evidence of publication bias exclude the possibility of reaching a definitive conclusion regarding the association of circumcision status and these sexually transmitted infections.
Full text links
Related Resources
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app