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Diamine derivatives containing imidazolidinylidene propanedinitrile as a new class of histamine H3 receptor antagonists. Part I.

Setsuya Sasho, Takashi Seishi, Mariko Kawamura, Ryo Hirose, Shinichiro Toki, Jun-ich Shimada
Bioorganic & Medicinal Chemistry Letters 2008 April 2
Novel diamine derivatives containing imidazolidinylidene propanedinitrile were synthesized and evaluated for histamine H(3) receptor-binding affinities. High-affinity ligands 3d, 3k, and 3n showed potent H(3) receptor antagonism and excellent selectivity over human H(1), H(2) and H(4) receptors.

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