JOURNAL ARTICLE
REVIEW
Add like
Add dislike
Add to saved papers

Diagnostic tests in neonatal sepsis.

PURPOSE OF REVIEW: The present review examines the major developments in early detection of neonatal sepsis, with an emphasis on the utility of diagnostic laboratory markers in clinical practice.

RECENT FINDINGS: Measures of acute phase proteins, cytokines, cell surface antigens, and bacterial genomes have been used alone or in combination to improve diagnosis of neonatal sepsis. Most studies evaluating laboratory diagnostic markers are retrospective cohorts or single center experience with relatively small sample size. Interpretation of these studies is confounded by inconsistent definitions of sepsis, heterogeneous sample populations, and different thresholds for diagnostic markers. Furthermore, many diagnostic markers are not available for routine care, they require specialized analytical procedures, and are expensive to perform.

SUMMARY: A better understanding of the neonatal inflammatory response to sepsis and identification of sensitive and specific markers of inflammation or rapid microbe-specific diagnostic tests would assist in the early detection of neonatal sepsis and in safely withholding antibiotics for patients in whom sepsis is unlikely.

Full text links

We have located links that may give you full text access.
Can't access the paper?
Try logging in through your university/institutional subscription. For a smoother one-click institutional access experience, please use our mobile app.

For the best experience, use the Read mobile app

Mobile app image

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app

All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.

By using this service, you agree to our terms of use and privacy policy.

Your Privacy Choices Toggle icon

You can now claim free CME credits for this literature searchClaim now

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app