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Folliculosebaceous cystic hamartoma or trichofolliculoma? A spectrum of hamartomatous changes inducted by perifollicular stroma in the follicular epithelium.

BACKGROUND: Folliculosebaceous cystic hamartoma (FSCH) histologically resembles trichofolliculoma.

METHODS: The clinical and histologic characteristics of both tumors were studied retrospectively, comparing these findings with those of other similar follicular tumors described in the literature.

RESULTS: Fourteen cases of FSCH and 15 cases of trichofolliculoma were diagnosed over 5 years. FSCH were larger, of longer duration, located mostly in the head and neck region. Histologically, the two lesions had a similar architecture except for the presence of a secondary follicle in trichofolliculoma.

CONCLUSION: FSCH are probably more common than previously thought and may be part of a spectrum of cystic follicular tumors. The perifollicular stroma may influence differentiation of the cystic wall, resulting in a variety of follicular tumors with overlapping features.

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