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Identification of loci associated with schizophrenia by genome-wide association and follow-up.

Michael C O'Donovan, Nicholas Craddock, Nadine Norton, Hywel Williams, Timothy Peirce, Valentina Moskvina, Ivan Nikolov, Marian Hamshere, Liam Carroll, Lyudmila Georgieva, Sarah Dwyer, Peter Holmans, Jonathan L Marchini, Chris C A Spencer, Bryan Howie, Hin-Tak Leung, Annette M Hartmann, Hans-Jürgen Möller, Derek W Morris, Yongyong Shi, GuoYin Feng, Per Hoffmann, Peter Propping, Catalina Vasilescu, Wolfgang Maier, Marcella Rietschel, Stanley Zammit, Johannes Schumacher, Emma M Quinn, Thomas G Schulze, Nigel M Williams, Ina Giegling, Nakao Iwata, Masashi Ikeda, Ariel Darvasi, Sagiv Shifman, Lin He, Jubao Duan, Alan R Sanders, Douglas F Levinson, Pablo V Gejman, Sven Cichon, Markus M Nöthen, Michael Gill, Aiden Corvin, Dan Rujescu, George Kirov, Michael J Owen, Nancy G Buccola, Bryan J Mowry, Robert Freedman, Farooq Amin, Donald W Black, Jeremy M Silverman, William F Byerley, C Robert Cloninger
Nature Genetics 2008 September
We carried out a genome-wide association study of schizophrenia (479 cases, 2,937 controls) and tested loci with P < 10(-5) in up to 16,726 additional subjects. Of 12 loci followed up, 3 had strong independent support (P < 5 x 10(-4)), and the overall pattern of replication was unlikely to occur by chance (P = 9 x 10(-8)). Meta-analysis provided strongest evidence for association around ZNF804A (P = 1.61 x 10(-7)) and this strengthened when the affected phenotype included bipolar disorder (P = 9.96 x 10(-9)).

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