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Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Variation near complement factor I is associated with risk of advanced AMD.
European Journal of Human Genetics : EJHG 2009 January
A case-control association study for advanced age-related macular degeneration was conducted to explore several regions of interest identified by linkage. This analysis identified a single nucleotide polymorphism just 3' of complement factor I on chromosome 4 showing significant association (P<10(-7)). Sequencing was performed on coding exons in linkage disequilibrium with the detected association. No obvious functional variation was discovered that could be the proximate cause of the association, suggesting a noncoding regulatory mechanism.
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