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Thrombocytosis associated with malignant ovarian lesions within a pediatric/adolescent population.
Journal of Pediatric and Adolescent Gynecology 2008 October
STUDY OBJECTIVE: To determine if there is an association between pediatric ovarian malignancies and elevated platelet counts:
DESIGN: Retrospective chart review.
SETTING: Large referral children's hospital.
PARTICIPANTS: 154 patients taken to the operating room between February 1993 and February 2006 with an adnexal mass where ovarian tissue was submitted for pathological analysis.
MAIN OUTCOME MEASURES: The principle outcome was the presence of ovarian malignancy.
RESULTS: We found that there is an increase in thrombocytosis among individuals with ovarian malignancy, with as high as 33% of those with ovarian germ cell tumors demonstrating preoperative thrombocytosis.
CONCLUSION: These results suggest that thrombocytosis may be a useful marker for ovarian malignancy in this population. Further studies will be needed to determine if there is any prognostic value to thrombocytosis among these patients, with a potential value for counseling and future intervention based on these findings.
DESIGN: Retrospective chart review.
SETTING: Large referral children's hospital.
PARTICIPANTS: 154 patients taken to the operating room between February 1993 and February 2006 with an adnexal mass where ovarian tissue was submitted for pathological analysis.
MAIN OUTCOME MEASURES: The principle outcome was the presence of ovarian malignancy.
RESULTS: We found that there is an increase in thrombocytosis among individuals with ovarian malignancy, with as high as 33% of those with ovarian germ cell tumors demonstrating preoperative thrombocytosis.
CONCLUSION: These results suggest that thrombocytosis may be a useful marker for ovarian malignancy in this population. Further studies will be needed to determine if there is any prognostic value to thrombocytosis among these patients, with a potential value for counseling and future intervention based on these findings.
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