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Parotid gland injections of botulinum toxin a are effective in treating sialorrhea in amyotrophic lateral sclerosis.
Journal of Clinical Neuromuscular Disease 2005 December
OBJECTIVE: : The objective of this study was to determine the safety and efficacy of botulinum toxin A in ameliorating refractory sialorrhea and improving quality of life in patients with amyotrophic lateral sclerosis.
MATERIALS AND METHODS: : Six patients with bulbar ALS received bilateral parotid gland injections of botulinum toxin A.
RESULTS: : No adverse effects occurred. Tissue use decreased in 5 of 7 patients at a dose of 10 units and in 3 of 4 patients at a dose of 20 units. Self-reported quality of life did not change in most.
CONCLUSIONS: : Parotid gland injections of botulinum toxin appear safe and may be helpful in some patients with ALS for the treatment of sialorrhea.
MATERIALS AND METHODS: : Six patients with bulbar ALS received bilateral parotid gland injections of botulinum toxin A.
RESULTS: : No adverse effects occurred. Tissue use decreased in 5 of 7 patients at a dose of 10 units and in 3 of 4 patients at a dose of 20 units. Self-reported quality of life did not change in most.
CONCLUSIONS: : Parotid gland injections of botulinum toxin appear safe and may be helpful in some patients with ALS for the treatment of sialorrhea.
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