Update on human infections caused by intestinal protozoa.

PURPOSE OF REVIEW: To update the reader on the recent literature discussing human infections due to intestinal protozoa.

RECENT FINDINGS: Diarrheal diseases due to intestinal protozoa cause significant morbidity and mortality worldwide in a variety of patient populations. New literature on key pathogens Cryptosporidium, Cyclospora, Isospora, Giardia, and Entamoeba histolytica are discussed.

SUMMARY: The recent medical literature on these pathogens has focused on new advances in understanding human genetic markers associated with susceptibility to infection and the use of molecular diagnostic techniques for both outbreak investigations (molecular epidemiology) and to understand the variability of clinical disease within species and subspecies.