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Safety of bisphosphonates in the treatment of osteoporosis.

Robert R Recker, E Michael Lewiecki, Paul D Miller, James Reiffel
American Journal of Medicine 2009 Februrary
In this review 4 experts consider the major safety concerns relating to bisphosphonate therapy for osteoporosis. Specific topics covered are skeletal safety (particularly with respect to atypical fractures and delayed healing), gastrointestinal intolerance, hypocalcemia, acute-phase (i.e., postdose) reactions, chronic musculoskeletal pain, renal safety, and cardiovascular safety (specifically, atrial fibrillation).

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