Epidemiology of bisphosphonate-related osteonecrosis of the jaws: the utility of a national registry.

PURPOSE: Little is known about the epidemiology of osteonecrosis of the jaws. To date, no population-based studies have rigorously evaluated risk factors, treatment factors, or outcomes. We aimed to perform such a study.

MATERIALS AND METHODS: We reviewed the literature for epidemiologic studies on osteonecrosis of the jaws.

RESULTS: Current epidemiologic information is generally derived from anecdotal reports or case series from small institutions. Estimates that have been provided in some reports have questionable validity because of a lack of standardized case definitions, clearly defined source populations, and clear methods for obtaining (or confirming) full reporting. Population-based prospective registries are capable of answering and informing several of the outstanding questions about bisphosphonate-related osteonecrosis of the jaws/osteonecrosis of the jaws.

CONCLUSION: A population-based registry that collects systematic information on patient characteristics, treatments, and outcomes is essential to filling the gaps in our knowledge and understanding of bisphosphonate-related osteonecrosis of the jaws.