Astemizole-induced cardiac conduction disturbances in a child.

The newly available antihistamine astemizole (Hismanal) has been previously associated with hemodynamically significant cardiac tachydysrhythmias. We describe a 3-year-old girl who developed multiple different cardiac dysrhythmias after an astemizole overdose. No hemodynamic compromise occurred, and the electrocardiogram returned to normal without use of antiarrhythmic agents within 7 hours.