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Evaluation Study
Journal Article
Review
Can we use statins to prevent stroke in Fabry disease?
Journal of Inherited Metabolic Disease 2009 August
UNLABELLED: Fabry disease is a rare, X-linked lysosomal storage disease caused by an inborn deficiency of alpha-galactosidase A, which results in the progressive accumulation of globotriaosylceramide and other neutral glycolipids in a range of cells and tissues. In association with the renal and cardiac insufficiency, cerebrovascular complications can result in the death of the patients. Several mechanisms causing vascular damage that leads to the development of deep-white matter lesions have been described. Recent clinical trials strongly suggest that statins protect against stroke by neuroprotective properties or pleiotropic effects.
AIM: To evaluate evidence and potential beneficial effects of statins in the vasculopathy of Fabry disease.
AIM: To evaluate evidence and potential beneficial effects of statins in the vasculopathy of Fabry disease.
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