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COMMENT
JOURNAL ARTICLE
Pain: Do ACE inhibitors exacerbate complex regional pain syndrome?
Nature Reviews. Neurology 2009 June
Complex regional pain syndrome is a chronic condition arising mainly after tissue injury and involves both inflammatory and neurogenic factors. Use of angiotensin-converting-enzyme inhibitors has been associated with an increased risk of developing the chronic pain condition, which suggests possible roles for substance P and bradykinin in the underlying pathogenic process.
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