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Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
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A sequence variant in ZFHX3 on 16q22 associates with atrial fibrillation and ischemic stroke.

Daniel F Gudbjartsson, Hilma Holm, Solveig Gretarsdottir, Gudmar Thorleifsson, G Bragi Walters, Gudmundur Thorgeirsson, Jeffrey Gulcher, Ellisiv B Mathiesen, Inger Njølstad, Audhild Nyrnes, Tom Wilsgaard, Erin M Hald, Kristian Hveem, Camilla Stoltenberg, Gayle Kucera, Tanya Stubblefield, Shannon Carter, Dan Roden, Maggie C Y Ng, Larry Baum, Wing Yee So, Ka Sing Wong, Juliana C N Chan, Christian Gieger, H-Erich Wichmann, Andreas Gschwendtner, Martin Dichgans, Gregor Kuhlenbäumer, Klaus Berger, E Bernd Ringelstein, Steve Bevan, Hugh S Markus, Konstantinos Kostulas, Jan Hillert, Sigurlaug Sveinbjörnsdóttir, Einar M Valdimarsson, Maja-Lisa Løchen, Ronald C W Ma, Dawood Darbar, Augustine Kong, David O Arnar, Unnur Thorsteinsdottir, Kari Stefansson
Nature Genetics 2009 August
We expanded our genome-wide association study on atrial fibrillation (AF) in Iceland, which previously identified risk variants on 4q25, and tested the most significant associations in samples from Iceland, Norway and the United States. A variant in the ZFHX3 gene on chromosome 16q22, rs7193343-T, associated significantly with AF (odds ratio OR = 1.21, P = 1.4 x 10(-10)). This variant also associated with ischemic stroke (OR = 1.11, P = 0.00054) and cardioembolic stroke (OR = 1.22, P = 0.00021) in a combined analysis of five stroke samples.

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