We have located links that may give you full text access.
Unique histologic variants of cutaneous Kaposi sarcoma.
American Journal of Dermatopathology 2010 May
BACKGROUND: Kaposi sarcoma (KS) is a low-grade angioproliferative neoplasm derived from lymphatic endothelium. Lesions progress from early patch stage into plaques that ultimately form tumor nodules. Several histological variants of KS have been described. The aim of this study is to describe 5 new histopathologic variants of cutaneous KS.
METHOD: Skin biopsy material submitted to a South African dermatopathology practice diagnostic of KS was reviewed. Formalin-fixed, paraffin-embedded tissue was routinely processed and stained with hematoxylin and eosin. Confirmatory immunohistochemical stains included CD31 and latent nuclear antigen-1 (human herpesvirus 8).
RESULTS: All biopsies were procured from HIV-positive patients with a clinical diagnosis of cutaneous KS tumor. Five distinct histologic KS variants, not previously well characterized in the literature, were identified including glomeruloid KS, telangiectatic KS, ecchymotic KS, KS with myoid nodules, and pigmented KS. Tumor cells in all of these variants were immunoreactive for CD31 and latent nuclear antigen-1.
CONCLUSIONS: These unique cases highlight the ability of KS to exhibit variable histomorphology. Their clinical significance requires further study. Dermatopathologists should be aware of these newly described variants to avoid the potential for their misdiagnosis.
METHOD: Skin biopsy material submitted to a South African dermatopathology practice diagnostic of KS was reviewed. Formalin-fixed, paraffin-embedded tissue was routinely processed and stained with hematoxylin and eosin. Confirmatory immunohistochemical stains included CD31 and latent nuclear antigen-1 (human herpesvirus 8).
RESULTS: All biopsies were procured from HIV-positive patients with a clinical diagnosis of cutaneous KS tumor. Five distinct histologic KS variants, not previously well characterized in the literature, were identified including glomeruloid KS, telangiectatic KS, ecchymotic KS, KS with myoid nodules, and pigmented KS. Tumor cells in all of these variants were immunoreactive for CD31 and latent nuclear antigen-1.
CONCLUSIONS: These unique cases highlight the ability of KS to exhibit variable histomorphology. Their clinical significance requires further study. Dermatopathologists should be aware of these newly described variants to avoid the potential for their misdiagnosis.
Full text links
Trending Papers
A Personalized Approach to the Management of Congestion in Acute Heart Failure.Heart International 2023
Potential Mechanisms of the Protective Effects of the Cardiometabolic Drugs Type-2 Sodium-Glucose Transporter Inhibitors and Glucagon-like Peptide-1 Receptor Agonists in Heart Failure.International Journal of Molecular Sciences 2024 Februrary 21
The Effect of Albumin Administration in Critically Ill Patients: A Retrospective Single-Center Analysis.Critical Care Medicine 2024 Februrary 8
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app