A consensus on criteria for cure of acromegaly.

A Giustina, P Chanson, M D Bronstein, A Klibanski, S Lamberts, F F Casanueva, P Trainer, E Ghigo, K Ho, S Melmed

Journal of Clinical Endocrinology and Metabolism 2010 July

OBJECTIVE: The Acromegaly Consensus Group met in April 2009 to revisit the guidelines on criteria for cure as defined in 2000.

PARTICIPANTS: Participants included 74 neurosurgeons and endocrinologists with extensive experience of treating acromegaly. EVIDENCE/CONSENSUS PROCESS: Relevant assays, biochemical measures, clinical outcomes, and definition of disease control were discussed, based on the available published evidence, and the strength of consensus statements was rated.

CONCLUSIONS: Criteria to define active acromegaly and disease control were agreed, and several significant changes were made to the 2000 guidelines. Appropriate methods of measuring and achieving disease control were summarized.

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