We have located links that may give you full text access.
JOURNAL ARTICLE
REVIEW
Genetic variation in pro-inflammatory cytokines and meningococcal sepsis.
Current Opinion in Infectious Diseases 2010 June
PURPOSE OF REVIEW: Pro-inflammatory cytokines are an essential component of host defence in patients who are susceptible to meningococcal disease. This review summarizes what is currently known about genetic variations in genes encoding these defensive proteins and focuses on recent work investigating the potential role polymorphisms may play insusceptibility and severity of the disease.
RECENT FINDINGS: A recently developed porcine model revealed significant cytokine derangement early in severe meningococcal sepsis raising the suggestion of a causative role for maladaptive cytokine release in the disease course. In patients who survive septic shock caused by the meningococcus there is a low innate production capacity for interleukin-1beta. Several polymorphisms have been identified in genes encoding for pro-inflammatory cytokines, and recently studies have shown association with susceptibility to infection in polymorphism at both IL-1RA (+2018) and TNF (-308).
SUMMARY: Recent work is adding to the growing evidence that genetic variation in pro-inflammatory cytokines has a role in susceptibility and survival in meningococcal disease. However, data need to be interpreted with caution as there are many confounding factors, sample sizes are often small and there are challenges in identifying suitable control groups.
RECENT FINDINGS: A recently developed porcine model revealed significant cytokine derangement early in severe meningococcal sepsis raising the suggestion of a causative role for maladaptive cytokine release in the disease course. In patients who survive septic shock caused by the meningococcus there is a low innate production capacity for interleukin-1beta. Several polymorphisms have been identified in genes encoding for pro-inflammatory cytokines, and recently studies have shown association with susceptibility to infection in polymorphism at both IL-1RA (+2018) and TNF (-308).
SUMMARY: Recent work is adding to the growing evidence that genetic variation in pro-inflammatory cytokines has a role in susceptibility and survival in meningococcal disease. However, data need to be interpreted with caution as there are many confounding factors, sample sizes are often small and there are challenges in identifying suitable control groups.
Full text links
Related Resources
Trending Papers
Heart failure with preserved ejection fraction: diagnosis, risk assessment, and treatment.Clinical Research in Cardiology : Official Journal of the German Cardiac Society 2024 April 12
Proximal versus distal diuretics in congestive heart failure.Nephrology, Dialysis, Transplantation 2024 Februrary 30
World Health Organization and International Consensus Classification of eosinophilic disorders: 2024 update on diagnosis, risk stratification, and management.American Journal of Hematology 2024 March 30
Efficacy and safety of pharmacotherapy in chronic insomnia: A review of clinical guidelines and case reports.Mental Health Clinician 2023 October
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app