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Serologic assays specific to immunoglobulin M antibodies against hepatitis E virus: pangenotypic evaluation of performances.

Jan Drobeniuc, Jihong Meng, Gábor Reuter, Tracy Greene-Montfort, Natasha Khudyakova, Zoya Dimitrova, Saleem Kamili, Chong-Gee Teo
Clinical Infectious Diseases 2010 August 2
Six immunoassays for detecting immunoglobulin M antibodies to hepatitis E virus were evaluated. Serum samples representing acute infection by each of the 4 viral genotypes as well as nonacute hepatitis E virus infection constituted the test panels. Diagnostic sensitivities and specificities as well as interassay agreement varied widely. Analytical sensitivity limits also were determined and were found to be particularly disparate.

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