Treatment of oral florid papillomatosis with systemic administration of photocarcinorin: an effective photodynamic therapy.

OBJECTIVES: To evaluate the safety and effect of systemic administration of photosensitizer Photocarcinorin (PsD-007) in the treatment of oral florid papillomatosis (OFP).

BACKGROUND: OFP is a rare and refractory disease characterized by multiple papillomatous lesions. The outcomes of many methods for OFP are not satisfactory.

MATERIALS AND METHODS: Photosensitizer Photocarcinorin (5 mg/kg) was intravenously injected into a 59-year-old woman with widespread OFP, and the lesions were irradiated for 10 min by using a 635-nm laser beam of 177 mW/cm(2) intensity and 106.2 J/cm(2) energy density. The therapy was performed once a month for 3 months in total.

RESULTS: After three courses, the small lesions disappeared, and the larger ones were reduced by ≥80%. The adverse effects were minimal.

CONCLUSIONS: Systemic PDT is an effective and successful treatment modality for OFP, especially in elderly patients.