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Upper urinary tract infections are associated with RANTES promoter polymorphism.

Sonia Centi, Susanna Negrisolo, Alejandra Stefanic, Elisa Benetti, Walburga Cassar, Liviana Da Dalt, Waifro Rigamonti, Pietro Zucchetta, Giovanni Montini, Luisa Murer, Lina Artifoni
Journal of Pediatrics 2010 December
We evaluated the association between MCP-1, CCR2, RANTES, and CCR5 gene polymorphisms and upper urinary tract infection in 273 children recruited in Northeast Italy. Statistical analysis of RANTES-403 G>A genotype frequencies showed that children carrying the RANTES-403 G allele are at higher risk for urinary tract infection, irrespective of vesicoureteral reflux.

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