Characteristics of patients with oseltamivir-resistant pandemic (H1N1) 2009, United States.

Samuel B Graitcer, Larisa Gubareva, Laurie Kamimoto, Saumil Doshi, Meredith Vandermeer, Janice Louie, Christine Waters, Zack Moore, Katrina Sleeman, Margaret Okomo-Adhiambo, Steven A Marshall, Kirsten St George, Chao Yang Pan, Jennifer M LaPlante, Alexander Klimov, Alicia M Fry

Emerging Infectious Diseases 2011 Februrary

During April 2009-June 2010, thirty-seven (0.5%) of 6,740 pandemic (H1N1) 2009 viruses submitted to a US surveillance system were oseltamivir resistant. Most patients with oseltamivir-resistant infections were severely immunocompromised (76%) and had received oseltamivir before specimen collection (89%). No evidence was found for community circulation of resistant viruses; only 4 (unlinked) patients had no oseltamivir exposure.

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