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Case Reports
Journal Article
The first successful paternity through in vitro fertilization-intracytoplasmic sperm injection with a man homozygous for the 5α-reductase-2 gene mutation.
Fertility and Sterility 2011 May
OBJECTIVE: To report a case of successful paternity from a male homozygous for 5α-reductase-2 deficiency.
DESIGN: Case report.
SETTING: Academic center, division of reproductive endocrinology.
PATIENT(S): A 45-year-old Dominican man and his 32-year-old wife.
INTERVENTION(S): In vitro fertilization and intracytoplasmic sperm injection.
MAIN OUTCOME MEASURE(S): Pregnancy.
RESULT(S): Viable twin gestation.
CONCLUSION(S): Men homozygous for 5α-reductase-2 deficiency can achieve biologic paternity through in vitro fertilization with intracytoplasmic sperm injection despite severely abnormal semen parameters.
DESIGN: Case report.
SETTING: Academic center, division of reproductive endocrinology.
PATIENT(S): A 45-year-old Dominican man and his 32-year-old wife.
INTERVENTION(S): In vitro fertilization and intracytoplasmic sperm injection.
MAIN OUTCOME MEASURE(S): Pregnancy.
RESULT(S): Viable twin gestation.
CONCLUSION(S): Men homozygous for 5α-reductase-2 deficiency can achieve biologic paternity through in vitro fertilization with intracytoplasmic sperm injection despite severely abnormal semen parameters.
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